| 25/09/2021 |  |
SpeziaSpezia | 1 | x | 2 | AC MilanAC Milan |  |
||
| 25/09/2021 |  |
InternazionaleInternazionale | 2 | x | 2 | AtalantaAtalanta |  |
||
| 25/09/2021 |  |
GenoaGenoa | 3 | x | 3 | Hellas VeronaHellas Verona |  |
||
| 26/09/2021 |  |
UdineseUdinese | 0 | x | 1 | FiorentinaFiorentina |  |
||
| 26/09/2021 |  |
LazioLazio | 3 | x | 2 | AS RomaAS Roma |  |
||
| 26/09/2021 |  |
NapoliNapoli | 2 | x | 0 | CagliariCagliari |  |