| 22/10/2021 |  |
Saint-ÉtienneSaint-Étienne | 2 | x | 2 | AngersAngers |  |
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| 23/10/2021 |  |
NantesNantes | 2 | x | 1 |  |
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| 23/10/2021 |  |
LilleLille | 1 | x | 1 | BrestBrest |  |
||
| 24/10/2021 |  |
NiceNice | 3 | x | 2 | LyonLyon |  |
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| 24/10/2021 |  |
LensLens | 4 | x | 1 | MetzMetz |  |
||
| 24/10/2021 |  |
Stade RennaisStade Rennais | 1 | x | 0 | StrasbourgStrasbourg |  |
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| 24/10/2021 |  |
LorientLorient | 1 | x | 1 | BordeauxBordeaux |  |
||
| 24/10/2021 |  |
Stade de ReimsReims | 1 | x | 2 | |
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| 24/10/2021 |  |
AS MonacoAS Monaco | 3 | x | 1 | MontpellierMontpellier |  |